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Title: Dietary fat in relation to fatty acid composition of red cells and adipose tissue in colorectal cancer
Authors: Neoptolemos, J. P.
Clayton, H.
Heagerty, A. M.
Nicholson, M. J.
Johnson, B.
Mason, J.
Manson, K.
James, R. F. L.
Bell, P. R. F.
First Published: Nov-1988
Publisher: Cancer Research UK
Citation: British Journal of Cancer, (1988) 58, 575–579.
Abstract: Fatty acids were determined in erthrocytes in 49 patients with colorectal cancer and compared with age and sex-matched controls. Marginally increased levels of stearic acid (P = 0.057) and oleic acid (P = 0.064) and decreased arachidonic acid (P = 0.043) occurred in cancer patients. There was no difference in the stearic to oleic acid ratio between the two groups. Dietary intake, assessed by dietary recall and adipose tissue analysis was also not different. In control subjects the polyunsaturated:saturated (P:S) fatty acid ratio correlated between diet and adipose tissue (P less than 0.01, at least). In contrast cancer patients showed different correlations; in particular dietary and erythrocyte P:S fatty acid ratios correlated (P less than 0.01). These findings may indicate disturbed fat metabolism in cancer patients. The erythrocyte stearic to oleic acid ratio is of no diagnostic value.
DOI Link: 10.1038/bjc.1988.262
ISSN: 0007-0920
eISSN: 1532-1827
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Creative Commons “Attribution Non-Commercial No Derivatives” licence CC BY-NC-ND, further details of which can be found via the following link: Archived with reference to SHERPA/RoMEO and publisher website.
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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