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Title: Detection of chromosomal 7 loss in myelodysplasia using an extremely polymorphic DNA probe
Authors: Thein1, S. L.
Oscier, D. G.
Jeffreys, A. J.
Hesketh, C.
Pilkington, S.
Summers, C.
Fitchett, M.
Wainscoat, J. S .
First Published: Feb-1988
Publisher: Cancer Research UK, Nature Publishing Group
Citation: British Journal of Cancer (1988) 57, 131–134
Abstract: Chromosomal loss is a characteristic feature of the myelodysplastic syndromes (MDS). A method is described which detects chromosomal 7 loss in MDS by DNA analysis using a specific hypervariable region gene probe which has been cloned from a human DNA fingerprint. Loss of one of the chromosomal 7 homologues was demonstrated in 10/118 MDS patients; the ten patients include all the five patients which had previously been shown to have monosomy 7 by cytogenetic analysis. This technique makes it feasible to study serial samples from large numbers of patients for loss of chromosomal material and could be readily applied to the study of other human malignancies.
DOI Link: 10.1038/bjc.1988.27
ISSN: 0007-0920
eISSN: 1532-1827
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Creative Commons “Attribution Non-Commercial No Derivatives” licence CC BY-NC-ND, further details of which can be found via the following link: Archived with reference to SHERPA/RoMEO and publisher website.
Appears in Collections:Published Articles, Dept. of Genetics

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