Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/38942
Title: West Midlands Oncology Association trials of adjuvant chemotherapy in operable breast cancer: results after a median follow-up of 7 years. II. Patients without involved axillary lymph nodes
Authors: Morrison, J. M.
Howell, A.
Kelly, K. A.
Grieve, R. J.
Monypenny, I. J.
Walker, R. A.
Waterhouse, J. A. H.
First Published: Dec-1989
Publisher: Cancer Research UK, Nature Publishing Group
Citation: British Journal of Cancer (1989) 60, 919–924.
Abstract: The aim of this study was to test the effectiveness of a regimen of combination chemotherapy when given as an adjuvant treatment after mastectomy to patients with histologically negative axillary lymph nodes. A total of 574 patients with cancer of the breast and no involvement of axillary lymph nodes were randomised, after simple mastectomy with axillary sampling, to receive either no adjuvant treatment or oral fluorouracil 500 mg, methotrexate 25 mg and chlorambucil 10 mg p.o. on day 1 and fluorouracil 500 mg and chlorambucil 10 mg p.o. on day 2 (LMF) every 21 days for eight cycles. Randomisation was stratified according to menopausal status and tumour size. Treatment was started within 14 days of surgery in 97% of patients. Ninety per cent of patients received eight cycles of chemotherapy with no dose reduction. At a median follow-up of 7 years, there was no evidence that relapse-free or overall survival time were influenced by treatment.
DOI Link: 10.1038/bjc.1989.390
ISSN: 0007-0920
eISSN: 1532-1827
Links: http://www.nature.com/bjc/journal/v60/n6/abs/bjc1989390a.html
http://hdl.handle.net/2381/38942
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Creative Commons “Attribution Non-Commercial No Derivatives” licence CC BY-NC-ND, further details of which can be found via the following link: http://creativecommons.org/licenses/by-nc-nd/4.0/ Archived with reference to SHERPA/RoMEO and publisher website.
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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