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Title: Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T.
Authors: Burns, J. S.
Lemoine, L.
Lemoine, N. R.
Williams, E. D.
Wynford-Thomas, D.
First Published: May-1989
Publisher: Cancer Research UK, Nature Publishing Group
Citation: British Journal of Cancer (1989) 59, 755–760.
Abstract: A recombinant murine retroviral vector encoding the SV40 virus large T antigen was used to infect stably an immortal line of differentiated rat thyroid epithelial cells, FRTL-5. Expression of SV40 T transformed these cells to anchorage independence and tumorigenicity but did not alter morphology or abolish tissue-specific functions and growth factor requirements. The resulting phenotype provides a model of well-differentiated human thyroid cancer.
DOI Link: 10.1038/bjc.1989.158
ISSN: 0007-0920
eISSN: 1532-1827
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Creative Commons “Attribution Non-Commercial No Derivatives” licence CC BY-NC-ND, further details of which can be found via the following link: Archived with reference to SHERPA/RoMEO and publisher website.
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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