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|Title:||Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T.|
|Authors:||Burns, J. S.|
Lemoine, N. R.
Williams, E. D.
|Publisher:||Cancer Research UK, Nature Publishing Group|
|Citation:||British Journal of Cancer (1989) 59, 755–760.|
|Abstract:||A recombinant murine retroviral vector encoding the SV40 virus large T antigen was used to infect stably an immortal line of differentiated rat thyroid epithelial cells, FRTL-5. Expression of SV40 T transformed these cells to anchorage independence and tumorigenicity but did not alter morphology or abolish tissue-specific functions and growth factor requirements. The resulting phenotype provides a model of well-differentiated human thyroid cancer.|
|Rights:||Creative Commons “Attribution Non-Commercial No Derivatives” licence CC BY-NC-ND, further details of which can be found via the following link: http://creativecommons.org/licenses/by-nc-nd/4.0/ Archived with reference to SHERPA/RoMEO and publisher website.|
|Appears in Collections:||Published Articles, College of Medicine, Biological Sciences and Psychology|
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