Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/38947
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dc.contributor.authorBurns, J. S.-
dc.contributor.authorLemoine, L.-
dc.contributor.authorLemoine, N. R.-
dc.contributor.authorWilliams, E. D.-
dc.contributor.authorWynford-Thomas, D.-
dc.date.accessioned2016-12-14T16:46:08Z-
dc.date.available2016-12-14T16:46:08Z-
dc.date.issued1989-05-
dc.identifier.citationBritish Journal of Cancer (1989) 59, 755–760.en
dc.identifier.issn0007-0920-
dc.identifier.urihttp://www.nature.com/bjc/journal/v59/n5/abs/bjc1989158a.htmlen
dc.identifier.urihttp://hdl.handle.net/2381/38947-
dc.description.abstractA recombinant murine retroviral vector encoding the SV40 virus large T antigen was used to infect stably an immortal line of differentiated rat thyroid epithelial cells, FRTL-5. Expression of SV40 T transformed these cells to anchorage independence and tumorigenicity but did not alter morphology or abolish tissue-specific functions and growth factor requirements. The resulting phenotype provides a model of well-differentiated human thyroid cancer.en
dc.description.sponsorshipWe are grateful to the Medical Research Council and to the Cancer Research Campaign of Great Britain for grant support.en
dc.language.isoenen
dc.publisherCancer Research UK, Nature Publishing Groupen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/2544221-
dc.rightsCreative Commons “Attribution Non-Commercial No Derivatives” licence CC BY-NC-ND, further details of which can be found via the following link: http://creativecommons.org/licenses/by-nc-nd/4.0/ Archived with reference to SHERPA/RoMEO and publisher website.en
dc.subjectAnimalsen
dc.subjectAntigens, Polyomavirus Transformingen
dc.subjectCell Lineen
dc.subjectCell Transformation, Neoplasticen
dc.subjectEpitheliumen
dc.subjectGenetic Vectorsen
dc.subjectPlasmidsen
dc.subjectRatsen
dc.subjectSimian virus 40en
dc.subjectThyroid Glanden
dc.subjectThyroid Neoplasmsen
dc.titleThyroid epithelial cell transformation by a retroviral vector expressing SV40 large T.en
dc.typeJournal Articleen
dc.identifier.doi10.1038/bjc.1989.158-
dc.identifier.eissn1532-1827-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeJournal Article;Research Support, Non-U.S. Gov't-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/No themeen
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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