Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/38950
Title: In vitro responsiveness to serum growth factors is inversely related to in vivo malignancy in human thyroid epithelial cells.
Authors: Dawson, T. P.
Wyllie, F. S.
Wynford-Thomas, D.
First Published: Jun-1991
Publisher: Cancer Research UK, Nature Publishing Group
Citation: British Journal of Cancer, 1991, 63 (6), pp. 897-900
Abstract: We have examined the proliferative response (DNA synthesis) of primary thyroid epithelial cultures to serum and a defined serum-substitute. These cultures were derived from normal human thyroid and from thyroid adenomas and carcinomas. All normal cultures showed a dose-dependent response, with a maximum 3H-thymidine labelling index of around 50%. Three out of the four adenomas demonstrated a much reduced or delayed response under the same conditions. In two carcinomas, labelling was never more than 5% and in one case was undetectable. This inverse relationship between the degree of in vivo malignancy and proliferative response in vitro has important implications for the interpretation of tissue culture models of epithelial neoplasia and also offers the potential for isolating novel growth factors specific for thyroid cancer cells.
DOI Link: 10.1038/bjc.1991.197
ISSN: 0007-0920
eISSN: 1532-1827
Links: http://www.nature.com/bjc/journal/v63/n6/abs/bjc1991197a.html
http://hdl.handle.net/2381/38950
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Creative Commons “Attribution Non-Commercial No Derivatives” licence CC BY-NC-ND, further details of which can be found via the following link: http://creativecommons.org/licenses/by-nc-nd/4.0/ Archived with reference to SHERPA/RoMEO and publisher website.
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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