Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/38962
Title: Does autocrine growth factor secretion form part of a mechanism which paradoxically protects against tumour development?
Authors: Dawson, T.
Wynford-Thomas, D.
First Published: Jun-1995
Publisher: Cancer Research UK, Nature Publishing Group
Citation: British Journal of Cancer (1995) 71, 1136–1141.
Abstract: Autocrine growth factor secretion has classically been considered as a mechanism by which tumour cells achieve autonomous growth. However, there is now considerable evidence that autocrine circuits operate in the growth regulation of normal adult tissues. Here we consider the possible advantages to the normal epithelial cell of utilising such an external growth factor circuit and suggest that autocrine growth factor secretion, when viewed in a multicellular context, could paradoxically form part of a mechanism for preventing tumour development.
DOI Link: 10.1038/bjc.1995.222
ISSN: 0007-0920
eISSN: 1532-1827
Links: http://www.nature.com/bjc/journal/v71/n6/abs/bjc1995222a.html
http://hdl.handle.net/2381/38962
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Creative Commons Attribution Non-Commercial Share Alike License
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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