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Title: Development of a lifestyle intervention using the MRC framework for diabetes prevention in people with impaired glucose regulation.
Authors: Troughton, Jacqui
Chatterjee, Sudesna
Hill, Siân E.
Daly, Heaher
Martin Stacey, Lorraine
Stone, Margaret A.
Patel, Naina
Khunti, Kamlesh
Yates, Thomas
Gray, Laura J.
Davies, Melanie J.
First Published: 17-Oct-2016
Publisher: Oxford University Press (OUP) for Royal Colleges of Physicians of the United Kingdom, Faculty of Public Health
Citation: Journal of Public Health, 2016, 38 (3), pp. 493-501
Abstract: BACKGROUND: We report development of a group-based lifestyle intervention, Let's Prevent, using the UK Medical Research Council (MRC) framework, and delivered by structured education to prevent type 2 diabetes mellitus (T2DM) in people with impaired glucose regulation (IGR) in a UK multi-ethnic population. METHODS: Diabetes Education and Self-Management for Ongoing and Newly Diagnosed (DESMOND) is the first national T2DM programme that meets National Institute for Health and Care Excellence criteria and formed the basis for Let's Prevent. An iterative cycle of initial development, piloting, collecting and collating qualitative and quantitative data, and reflection and modification, was used to inform and refine lifestyle intervention until it was fit for evaluation in a definitive randomized controlled trial (RCT). The programme encouraged IGR self-management using simple, non-technical language and visual aids. RESULTS: Qualitative and quantitative data suggested that intervention resulted in beneficial short-term behaviour change such as healthier eating patterns, improved health beliefs and greater participant motivation and empowerment. We also demonstrated that recruitment strategy and data collection methods were feasible for RCT implementation. CONCLUSIONS: Let's Prevent was developed following successful application of MRC framework criteria and the subsequent RCT will determine whether it is feasible, reliable and transferable from research into a real-world NHS primary healthcare setting. TRIAL REGISTRATION: ISRCTN80605705.
DOI Link: 10.1093/pubmed/fdv110
ISSN: 1741-3842
eISSN: 1741-3850
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: © The Author 2015. Published by Oxford University Press on behalf of Faculty of Public Health. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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