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Title: The Speed of Increasing milk Feeds: a randomised controlled trial
Authors: Abbott, Jane
Berrington, Janet
Bowler, Ursula
Boyle, Elaine
Dorling, Jon
Embleton, Nicholas
Juszczak, Edmund
Leaf, Alison
Linsell, Louise
Johnson, Samantha
McCormick, Kenny
McGuire, William
Roberts, Tracy
Stenson, Ben
First Published: 28-Jan-2017
Publisher: BioMed Central
Citation: BMC Pediatrics, 2017, 17(39)
Abstract: In the UK, 1-2% of infants are born very preterm (<32 weeks of gestation) or have very low birth weight (<1,500g). Very preterm infants are initially unable to be fed nutritional volumes of milk and therefore require intravenous nutrition. Milk feeding strategies influence several long and short term health outcomes including growth, survival, infection (associated with intravenous nutrition) and necrotising enterocolitis (NEC); with both infection and NEC being key predictive factors of long term disability. Currently there is no consistent strategy for feeding preterm infants across the UK. The SIFT trial will test two speeds of increasing milk feeds with the primary aim of determining effects on survival without moderate or severe neurodevelopmental disability at 24 months of age, corrected for prematurity. The trial will also examine many secondary outcomes including infection, NEC, time taken to reach full feeds and growth.
DOI Link: 10.1186/s12887-017-0794-z
ISSN: 1471-2431
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2017. This is an open-access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated..
Appears in Collections:Published Articles, Dept. of Health Sciences

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