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Title: Human placental growth hormone is increased in maternal serum at 20 weeks of gestation in pregnancies with large-for-gestational-age babies
Authors: Liao, Shutan
Vickers, Mark H.
Taylor, Rennae S.
Jones, Beatrix
Fraser, Mhoyra
McCowan, Lesley M. E.
Baker, Philip N.
Perry, Jo K.
First Published: 25-Jan-2017
Publisher: Taylor & Francis
Citation: Growth Factors, 2016, 34 (5-6), pp. 203-209
Abstract: To investigate the relationship between maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF)-1 and 2, IGF binding proteins (IGFBP)-1 and 3 and birth weight in appropriate-for-gestational-age (AGA), large-for-gestational-age (LGA) and small-for-gestational-age (SGA) cases in a nested case-control study. Maternal serum samples were selected from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Serum hormone concentrations were determined by ELISA. We found that maternal serum GH-V concentrations at 20 weeks of gestation in LGA pregnancies were significantly higher than in AGA and SGA pregnancies. Maternal GH-V concentrations were positively correlated to birth weights and customized birth weight centiles, while IGFBP-1 concentrations were inversely related to birth weights and customized birth weight centiles. Our findings suggest that maternal serum GH-V and IGFBP-1 concentrations at 20 weeks' gestation are associated with fetal growth.
DOI Link: 10.1080/08977194.2016.1273223
ISSN: 0897-7194
eISSN: 1029-2292
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2017, Informa UK Limited, trading as Taylor & Francis Group. Deposited with reference to the publisher’s open access archiving policy.
Description: The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

Files in This Item:
File Description SizeFormat 
revised LGA scope paper 22-11-2016.pdfPost-review (final submitted author manuscript)137.72 kBAdobe PDFView/Open
LGA paper figures 14-11-2016.pdfFigures25.85 kBAdobe PDFView/Open
SCOPE LGA tables 14-11-2016.pdfTables128.08 kBAdobe PDFView/Open

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