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Title: Use of magnesium sulfate before 32 weeks of gestation: A European population-based cohort study
Authors: Wolf, H. T.
Huusom, L.
Weber, T.
Piedvache, A.
Schmidt, S.
Norman, M.
Zeitlin, J.
Martens, E.
Martens, G.
Van Reempts, P.
Boerch, K.
Hasselager, A.
Pryds, O.
Toome, L.
Varendi, H.
Ancel, P. Y.
Blondel, B.
Burguet, A.
Jarreau, P. H.
Truffert, P.
Maier, R. F.
Misselwitz, B.
Gortner, L.
Baronciani, D.
Gargano, G.
Agostino, R.
DiLallo, D.
Franco, F.
Carnielli, V.
Cuttini, M.
Koopman-Esseboom, C.
Van Heijst, A.
Nijman, J.
Gadzinowski, J.
Mazela, J.
Graça, L. M.
MacHado, M. C.
Rodrigues, C.
Rodrigues, T.
Barros, H.
Bonamy, A. K.
Wilson, E.
Boyle, E.
Draper, E. S.
Manktelow, Bradley N.
Fenton, A. C.
Milligan, D. W. A.
Bonet, M.
First Published: 1-Jan-2017
Publisher: BMJ Publishing Group
Citation: BMJ Open, 2017, 7 (1)
Abstract: Objectives: The use of magnesium sulfate (MgSO4) in European obstetric units is unknown. We aimed to describe reported policies and actual use of MgSO4 in women delivering before 32 weeks of gestation by indication. Methods: We used data from the European Perinatal Intensive Care in Europe (EPICE) population-based cohort study of births before 32 weeks of gestation in 19 regions in 11 European countries. Data were collected from April 2011 to September 2012 from medical records and questionnaires. The study population comprised 720 women with severe preeclampsia, eclampsia or HELLP and 3658 without preeclampsia delivering from 24 to 31 weeks of gestation in 119 maternity units with 20 or more very preterm deliveries per year. Results: Among women with severe pre-eclampsia, eclampsia or HELLP, 255 (35.4%) received MgSO4 before delivery. 41% of units reported use of MgSO4 whenever possible for pre-eclampsia and administered MgSO4 more often than units reporting use sometimes. In women without pre-eclampsia, 95 (2.6%) received MgSO4. 9 units (7.6%) reported using MgSO4 for fetal neuroprotection whenever possible. In these units, the median rate of MgSO4 use for deliveries without severe pre-eclampsia, eclampsia and HELLP was 14.3%. Only 1 unit reported using MgSO4 as a first-line tocolytic. Among women without preeclampsia, MgSO4 use was not higher in women hospitalised before delivery for preterm labour. Conclusions: Severe pre-eclampsia, eclampsia or HELLP are not treated with MgSO4 as frequently as evidence-based medicine recommends. MgSO4 is seldom used for fetal neuroprotection, and is no longer used for tocolysis. To continuously lower morbidity, greater attention to use of MgSO4 is needed.
DOI Link: 10.1136/bmjopen-2016-013952
eISSN: 2044-6055
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2017. This is an open-access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Published Articles, Dept. of Health Sciences

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