Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/39553
Title: Associations of objectively measured moderate-to-vigorous-intensity physical activity and sedentary time with all-cause mortality in a population of adults at high risk of type 2 diabetes mellitus.
Authors: Bakrania, Kishan
Edwardson, Charlotte L.
Khunti, Kamlesh
Henson, Joseph
Stamatakis, Emmanuel
Hamer, Mark
Davies, Melanie J.
Yates, Thomas
First Published: 26-Jan-2017
Publisher: Elsevier
Citation: Preventive Medicine Reports, 2017, 5, pp. 285-288
Abstract: The relationships of physical activity and sedentary time with all-cause mortality in those at high risk of type 2 diabetes mellitus (T2DM) are unexplored. To address this gap in knowledge, we examined the associations of objectively measured moderate-to-vigorous-intensity physical activity (MVPA) and sedentary time with all-cause mortality in a population of adults at high risk of T2DM. In 2010-2011, 712 adults (Leicestershire, U.K.), identified as being at high risk of T2DM, consented to be followed up for mortality. MVPA and sedentary time were assessed by accelerometer; those with valid data (≥ 10 hours of wear-time/day with ≥ 4 days of data) were included. Cox proportional hazards regression models, adjusted for potential confounders, were used to investigate the independent associations of MVPA and sedentary time with all-cause mortality. 683 participants (250 females (36.6%)) were included and during a mean follow-up period of 5.7 years, 26 deaths were registered. Every 10% increase in MVPA time/day was associated with a 5% lower risk of all-cause mortality [Hazard Ratio (HR): 0.95 (95% Confidence Interval (95% CI): 0.91, 0.98); p = 0.004]; indicating that for the average adult in this cohort undertaking approximately 27.5 minutes of MVPA/day, this benefit would be associated with only 2.75 additional minutes of MVPA/day. Conversely, sedentary time showed no association with all-cause mortality [HR (every 10-minute increase in sedentary time/day): 0.99 (95% CI: 0.95, 1.03); p = 0.589]. These data support the importance of MVPA in adults at high risk of T2DM. The association between sedentary time and mortality in this population needs further investigation.
DOI Link: 10.1016/j.pmedr.2017.01.013
10.1016/j.pmedr.2017.01.013
ISSN: 2211-3355
eISSN: 2211-3355
Links: http://www.sciencedirect.com/science/article/pii/S2211335517300128
http://hdl.handle.net/2381/39553
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2017. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Description: Supplementary data to this article can be found online at http://dx.doi.org/10.1016/j.pmedr.2017.01.013.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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