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Title: Non-targeted metabolomics in sport and exercise science
Authors: Heaney, Liam M.
Deighton, Kevin
Suzuki, Toru
First Published: 27-Mar-2017
Publisher: Taylor & Francis for British Association of Sport and Exercise Sciences
Citation: Journal of Sports Sciences, 2017
Abstract: Metabolomics incorporates the study of metabolites that are produced and released through physiological processes at both the systemic and cellular level. Biological compounds at the metabolite level are of paramount interest in the sport and exercise sciences, although research in this field has rarely been referred to with the global ‘omics terminology. Commonly studied metabolites in exercise science are notably within cellular pathways for ATP production such as glycolysis (e.g. pyruvate and lactate), β-oxidation of free fatty acids (e.g. palmitate) and ketone bodies (e.g. β-hydroxybutyrate). Non-targeted metabolomic technologies are able to simultaneously analyse the large numbers of metabolites present in human biological samples such as plasma, urine and saliva. These analytical technologies predominately employ nuclear magnetic resonance spectroscopy and chromatography coupled to mass spectrometry. Performing experiments based on non-targeted methods allows for systemic metabolite changes to be analysed and compared to a particular physiological state (e.g. pre/post-exercise) and provides an opportunity to prospect for metabolite signatures that offer beneficial information for translation into an exercise science context, for both elite performance and public health monitoring. This narrative review provides an introduction to non-targeted metabolomic technologies and discusses current and potential applications in sport and exercise science.
DOI Link: 10.1080/02640414.2017.1305122
ISSN: 0264-0414
eISSN: 1466-447X
Embargo on file until: 27-Sep-2018
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2017, Taylor & Francis for British Association of Sport and Exercise Sciences. Deposited with reference to the publisher’s open access archiving policy.
Description: The file associated with this record is under embargo until 18 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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