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Title: Risk of developing chronic lymphocytic leukemia is influenced by HLA-A class I variation
Authors: Di Bernardo, Maria Chiara
Broderick, Peter
Harris, Shelley
Dyer, Martin J. S.
Matutes, Estella
Dearden, Claire
Catovsky, Daniel
Houlston, Richard S.
First Published: Jan-2013
Publisher: Nature Publishing Group
Citation: Leukemia, 2013, 27 (1), pp. 255-258
Abstract: [First paragraph] While chronic lymphocytic leukemia (CLL) is characterized by a strong familial risk, the genetic basis of inherited susceptibility to CLL is largely unknown. The increased risk of Hodgkin Lymphoma (HL) and non-Hodgkin Lymphoma (NHL) in relatives of CLL patients suggests a common etiology to B-cell lymphoproliferative disorders (LPDs) through HLA variation(1). Moreover, since B-cell proliferation is part of an adaptive immune response which can be initiated by major histocompatibility complex (MHC)-restricted T-cell activation, a possible influence of HLA on CLL pathogenesis is plausible.
DOI Link: 10.1038/leu.2012.173
ISSN: 0887-6924
eISSN: 1476-5551
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2013, Nature Publishing Group. Deposited with reference to the publisher’s open access archiving policy.
Description: Refer to Web version on PubMed Central for supplementary material.
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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