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|Title:||Risk of developing chronic lymphocytic leukemia is influenced by HLA-A class I variation|
|Authors:||Di Bernardo, Maria Chiara|
Dyer, Martin J. S.
Houlston, Richard S.
|Publisher:||Nature Publishing Group|
|Citation:||Leukemia, 2013, 27 (1), pp. 255-258|
|Abstract:||[First paragraph] While chronic lymphocytic leukemia (CLL) is characterized by a strong familial risk, the genetic basis of inherited susceptibility to CLL is largely unknown. The increased risk of Hodgkin Lymphoma (HL) and non-Hodgkin Lymphoma (NHL) in relatives of CLL patients suggests a common etiology to B-cell lymphoproliferative disorders (LPDs) through HLA variation(1). Moreover, since B-cell proliferation is part of an adaptive immune response which can be initiated by major histocompatibility complex (MHC)-restricted T-cell activation, a possible influence of HLA on CLL pathogenesis is plausible.|
|Rights:||Copyright © 2013, Nature Publishing Group. Deposited with reference to the publisher’s open access archiving policy.|
|Description:||Refer to Web version on PubMed Central for supplementary material.|
|Appears in Collections:||Published Articles, Dept. of Cancer Studies and Molecular Medicine|
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