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Title: Cellular activation of hypothalamic hypocretin/orexin neurons facilitates short-term spatial memory in mice.
Authors: Aitta-Aho, Teemu
Pappa, Elpiniki
Burdakov, Denis
Apergis-Schoute, John
First Published: 13-Oct-2016
Publisher: Elsevier
Citation: Neurobiology of Learning and Memory, 2016, 136, pp. 183-188
Abstract: The hypothalamic hypocretin/orexin (HO) system holds a central role in the regulation of several physiological functions critical for food-seeking behavior including mnemonic processes for effective foraging behavior. It is unclear however whether physiological increases in HO neuronal activity can support such processes. Using a designer rM3Ds receptor activation approach increasing HO neuronal activity resulted in improved short-term memory for novel locations. When tested on a non-spatial novelty object recognition task no significant difference was detected between groups indicating that hypothalamic HO neuronal activation can selectively facilitate short-term spatial memory for potentially supporting memory for locations during active exploration.
DOI Link: 10.1016/j.nlm.2016.10.005
ISSN: 1074-7427
eISSN: 1095-9564
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2016. This is an open-access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Reports, Dept. of Neuroscience, Psychology and Behaviour

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