Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/39739
Title: Cellular activation of hypothalamic hypocretin/orexin neurons facilitates short-term spatial memory in mice.
Authors: Aitta-Aho, Teemu
Pappa, Elpiniki
Burdakov, Denis
Apergis-Schoute, John
First Published: 13-Oct-2016
Publisher: Elsevier
Citation: Neurobiology of Learning and Memory, 2016, 136, pp. 183-188
Abstract: The hypothalamic hypocretin/orexin (HO) system holds a central role in the regulation of several physiological functions critical for food-seeking behavior including mnemonic processes for effective foraging behavior. It is unclear however whether physiological increases in HO neuronal activity can support such processes. Using a designer rM3Ds receptor activation approach increasing HO neuronal activity resulted in improved short-term memory for novel locations. When tested on a non-spatial novelty object recognition task no significant difference was detected between groups indicating that hypothalamic HO neuronal activation can selectively facilitate short-term spatial memory for potentially supporting memory for locations during active exploration.
DOI Link: 10.1016/j.nlm.2016.10.005
ISSN: 1074-7427
eISSN: 1095-9564
Links: http://www.sciencedirect.com/science/article/pii/S1074742716302507
http://hdl.handle.net/2381/39739
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2016. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Reports, Dept. of Neuroscience, Psychology and Behaviour

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