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Title: A Double Hit CD10-Negative B-Cell Lymphoma with t(3;8)(q27;q24) Leading to Juxtaposition of the BCL6 and MYC Loci Associated with Good Clinical Outcome
Authors: Sanders, Lucinda
Jayne, Sandrine
Kennedy, Ben
Miall, Fiona
Aukema, Sietse M.
Siebert, Reiner
Wagner, Simon D.
Dyer, Martin J. S.
First Published: 1-Oct-2014
Publisher: Hindawi Publishing Corporation
Citation: Case Reports in Hematology, 2014, Article ID 120714
Abstract: The WHO classification of lymphomas allows for a group of diseases that have features intermediate between those of Burkitt lymphoma and diffuse large B-cell lymphoma. These are a diverse group of diseases whose genetics and clinical course are yet to be fully described. We report an unusual case of high grade B-cell lymphoma, intermediate between DLBCL and BL, lacking CD10 expression in which the chromosomal translocation t(3;8)(q27;q24) was found to be the sole chromosomal abnormality. FISH analysis demonstrated juxtaposition of the BCL6 and MYC loci without obvious involvement of the IGH locus, suggesting constitutive MYC expression due to promoter substitution. The patient responded to intensive chemotherapy and remains in remission two years after finishing therapy.
DOI Link: 10.1155/2014/120714
ISSN: 2090-6560
eISSN: 2090-6579
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2014 Lucinda Sanders et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. .
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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