Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/39791
Title: Intracerebral hemorrhage location and outcome among INTERACT2 participants
Authors: Delcourt, Candice
Sato, Shoichiro
Zhang, Shihong
Sandset, Else Charlotte
Zheng, Danni
Chen, Xiaoying
Hackett, Maree L
Arima, Hisatomi
Hata, Jun
Heeley, Emma
Salman, Rustam Al-Shahi
Robinson, Thompson
Davies, Leo
Lavados, Pablo M.
Lindley, Richard I.
Stapf, Christian
Chalmers, John
Anderson, Craig S.
INTERACT2 Investigators
First Published: 24-Feb-2017
Publisher: American Academy of Neurology (AAN)
Citation: Neurology, 2017, 88 (15), pp. 1408-1414
Abstract: OBJECTIVE: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). METHODS: Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models. RESULTS: Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively). CONCLUSION: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule. CLINICALTRIALSGOV REGISTRATION: NCT00716079.
DOI Link: 10.1212/WNL.0000000000003771
ISSN: 0028-3878
eISSN: 1526-632X
Links: http://www.neurology.org/content/88/15/1408
http://hdl.handle.net/2381/39791
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2017. This is an open-access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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