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Title: The Leicester cerebral haemodynamics database: normative values and the influence of age and sex
Authors: Patel, Nikil
Panerai, Ronney B.
Haunton, Victoria
Katsogridakis, Emmanuel
Saeed, Nazia P.
Salinet, Angela
Brodie, Fiona
Syed, Nazia
D'Sa, Schnell
Robinson, Thompson G.
First Published: 11-Aug-2016
Publisher: IOP Publishing
Citation: Physiological Measurement, 2016, 37 (9), pp. 1485-1498
Abstract: Normative values of physiological parameters hold significance in modern day clinical decision-making. Lack of such normative values has been a major hurdle in the translation of research into clinical practice. A large database containing uniform recordings was constructed to allow more robust estimates of normative ranges and also assess the influence of age and sex. Doppler recordings were performed on healthy volunteers in the same laboratory, using similar protocols and equipment. Beat-to-beat blood pressure, heart-rate, electrocardiogram, and end-tidal CO2 were measured continuously. Bilateral insonation of the middle cerebral arteries (MCAs) was performed using TCD following a 15 min stabilisation, and a 5 min baseline recording. Good quality Doppler recordings for both MCAs were obtained in 129 participants (57 female) with a median age of 57 years (range 20-82). Age was found to influence baseline haemodynamic and transfer function analysis parameters. Cerebral blood flow velocity and critical closing pressure were the only sex-related differences found, which was significantly higher in females than males. Normative values for cerebral haemodynamic parameters have been defined in a large, healthy population. Such age/sex-defined normal values can be used to reduce the burden of collecting additional control data in future studies, as well as to identify disease-associated changes.
DOI Link: 10.1088/0967-3334/37/9/1485
ISSN: 0967-3334
eISSN: 1361-6579
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2016, IOP Publishing. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Description: The file associated with this record is embargoed until 12 months after the date of publication. The final published version may be available through the links above.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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