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Title: Human Group 2 innate lymphoid cells do not express the IL-5 receptor
Authors: Wright, Adam K. A.
Weston, Cathryn
Rana, Batika M. J.
Brightling, Christopher E.
Cousins, David J.
First Published: 10-May-2017
Publisher: Elsevier for American Academy of Allergy, Asthma and Immunology
Citation: Journal of Allergy and Clinical Immunology, 2017
Abstract: Group 2 innate lymphoid cells (ILC2s) are upstream regulators of IL-5-dependent eosinophil function in asthma. We’ve shown that ILC2s do not express the IL-5R and thus IL-5R- dependent therapeutic interventions (e.g. Benralizumab) are unlikely to be mediated directly on ILC2s.
DOI Link: 10.1016/j.jaci.2017.04.025
ISSN: 0091-6749
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2017. This is an open-access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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