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Title: Degree and Timing of Intensive Blood Pressure Lowering on Hematoma Growth in Intracerebral Hemorrhage: Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial-2 Results.
Authors: Carcel, Cheryl
Wang, Xia
Sato, Shoichiro
Stapf, Christian
Sandset, Else Charlotte
Delcourt, Candice
Arima, Hisatomi
Robinson, Thompson G.
Lavados, Pablo
Chalmers, John
Anderson, Craig S.
INTERACT2 Investigators*
First Published: 3-May-2016
Publisher: American Heart Association with 1. American Stroke Association 2. Lippincott, Williams & Wilkins
Citation: Stroke, 2016, 47 (6), pp. 1651-1653
Abstract: BACKGROUND AND PURPOSE: Degree and timing of blood pressure (BP) lowering treatment in relation to hematoma growth were investigated in the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial-2 (INTERACT2). METHODS: INTERACT2 was an international clinical trial of intensive (target systolic BP [SBP], <140 mm Hg) versus guideline-recommended (SBP, <180 mm Hg) BP lowering in 2839 patients within 6 hours of spontaneous intracerebral hemorrhage and elevated SBP (150-220 mm Hg), in which 964 had repeat cranial computed tomography at 24 hours. ANCOVA models assessed categories of SBP reduction and time to target SBP on 24-hour hematoma growth. RESULTS: Greater SBP reduction was associated with reduced hematoma growth (13.3, 5.0, and 3.0 mL for <10, 10-20, and ≥20 mm Hg, respectively; P trend<0.001). In the intensive treatment group (n=491), the least mean hematoma growth was in patients who achieved target SBP <1 hour (2.6 mL) versus to those in target at 1 to 6 (4.7 mL) and >6 hours (5.4 mL). The smallest mean absolute hematoma growth (2.0 mL) was in those achieving target SBP 5 to 8 times versus 3 to 4 (3.1 mL) and 0 to 2 times (5.2 mL). CONCLUSIONS: Intensive BP lowering with greater SBP reduction, which is achieved quickly and maintained consistently, seems to provide protection against hematoma growth for 24 hours. CLINICAL TRIAL REGISTRATION: URL: Unique identifier: NCT00716079.
DOI Link: 10.1161/STROKEAHA.116.013326
eISSN: 1524-4628
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2016, American Heart Association. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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