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Title: Early Blood Pressure Lowering Does Not Reduce Growth of Intraventricular Hemorrhage following Acute Intracerebral Hemorrhage: Results of the INTERACT Studies
Authors: Chan, Edward
Anderson, Craig S.
Wang, Xia
Arima, Hisatomi
Saxena, Anubhav
Moullaali, Tom J.
Delcourt, Candice
Wu, Guojun
Wang, Jinchao
Chen, Guofang
Lavados, Pablo M.
Stapf, Christian
Robinson, Thompson G.
Chalmers, John
INTERACT Investigators
First Published: 8-Sep-2016
Publisher: Karger Publishers Open Access
Citation: Cerebrovascular Diseases Extra, 2016, 6 (3), pp. 71-75
Abstract: BACKGROUND: Intraventricular hemorrhage (IVH) extension is common following acute intracerebral hemorrhage (ICH) and is associated with poor prognosis. AIM: To determine whether intensive blood pressure (BP)-lowering therapy reduces IVH growth. METHODS: Pooled analyses of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials (INTERACT1 and INTERACT2) computed tomography (CT) substudies; multicenter, open, controlled, randomized trials of patients with acute spontaneous ICH and elevated systolic BP, randomly assigned to intensive (<140 mm Hg) or guideline-based (<180 mm Hg) BP management. Participants had blinded central analyses of baseline and 24-hour CT. Association of BP lowering to IVH growth was assessed in analysis of covariance. RESULTS: There was no significant difference in adjusted mean IVH growth following intensive (n = 228) compared to guideline-recommended (n = 228) BP treatment (1.6 versus 2.2 ml, respectively; p = 0.56). Adjusted mean IVH growth was nonsignificantly greater in patients with a mean achieved systolic BP ≥160 mm Hg over 24 h (3.94 ml; p trend = 0.26). CONCLUSIONS: Early intensive BP-lowering treatment had no clear effect on IVH in acute ICH.
DOI Link: 10.1159/000448897
eISSN: 1664-5456
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2016. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License (, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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