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Title: New potentiometric sensor based on molecularly imprinted nanoparticles for cocaine detection
Authors: Smolinska-Kempisty, K.
Ahmad, O. S.
Guerreiro, A.
Karim, K.
Piletska, Elena
Piletsky, S.
First Published: 27-Apr-2017
Publisher: Elsevier
Citation: Biosensors and Bioelectronics, 2017, 96, pp. 49-54
Abstract: Here we present a potentiometric sensor for cocaine detection based on molecularly imprinted polymer nanoparticles (nanoMIPs) produced by the solid-phase imprinting method. The composition of polymers with high affinity for cocaine was optimised using molecular modelling. Four compositions were selected and polymers prepared using two protocols: chemical polymerisation in water and UV-initiated polymerisation in organic solvent. All synthesised nanoparticles had very good affinity to cocaine with dissociation constants between 0.6nM and 5.3nM. Imprinted polymers produced in organic solvent using acrylamide as a functional monomer demonstrated the highest yield and affinity, and so were selected for further sensor development. For this, nanoparticles were incorporated within a PVC matrix which was then used to prepare an ion-selective membrane integrated with a potentiometric transducer. It was demonstrated that the sensor was able to quantify cocaine in blood serum samples in the range of concentrations between 1nM and 1mM.
DOI Link: 10.1016/j.bios.2017.04.034
ISSN: 0956-5663
Embargo on file until: 27-Apr-2018
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © Elsevier, 2017. After an embargo period this version of the paper will be an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License (, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Description: The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, Dept. of Chemistry

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Cocaine paper.pdfPost-review (final submitted author manuscript)635.58 kBAdobe PDFView/Open
Supplementary information_cocaine.pdfPost-review (final submitted author manuscript)221.89 kBAdobe PDFView/Open

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