Please use this identifier to cite or link to this item:
Title: Dopamine dysregulation in the prefrontal cortex relates to cognitive deficits in the sub-chronic PCP-model for schizophrenia: A preliminary investigation
Authors: McLean, Samantha L.
Harte, Michael K.
Neill, Joanna C.
Young, Andrew M. J.
First Published: 1-Apr-2017
Publisher: SAGE Publications
Citation: Journal of Psychopharmacology, 2017, 31 (6), pp. 660-666
Abstract: Rationale: Dopamine dysregulation in the prefrontal cortex (PFC) plays an important role in cognitive dysfunction in schizophrenia. Sub-chronic phencyclidine (scPCP) treatment produces cognitive impairments in rodents and is a thoroughly validated animal model for cognitive deficits in schizophrenia. The aim of our study was to investigate the role of PFC dopamine in scPCP-induced deficits in a cognitive task of relevance to the disorder, novel object recognition (NOR). Methods: Twelve adult female Lister Hooded rats received scPCP (2 mg/kg) or vehicle via the intraperitoneal route twice daily for 7 days, followed by 7 days washout. In vivo microdialysis was carried out prior to, during and following the NOR task. Results: Vehicle rats successfully discriminated between novel and familiar objects and this was accompanied by a significant increase in dopamine in the PFC during the retention trial (p < 0.01). scPCP produced a significant deficit in NOR (p < 0.05 vs. control) and no PFC dopamine increase was observed. Conclusions: These data demonstrate an increase in dopamine during the retention trial in vehicle rats that was not observed in scPCP-treated rats accompanied by cognitive disruption in the scPCP group. This novel finding suggests a mechanism by which cognitive deficits are produced in this animal model and support its use for investigating disorders in which PFC dopamine is central to the pathophysiology.
DOI Link: 10.1177/0269881117704988
ISSN: 0269-8811
eISSN: 1461-7285
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © The Author(s) 2017. Deposited with reference to the publisher’s open access archiving policy.
Appears in Collections:Published Articles, Dept. of Neuroscience, Psychology and Behaviour

Files in This Item:
File Description SizeFormat 
McLean Harte Neill Young 2017.pdfPost-review (final submitted author manuscript)237.98 kBAdobe PDFView/Open

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.