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Title: Feasibility of progesterone treatment for ischaemic stroke
Authors: Gibson, Claire L.
Bath, Philip M.
First Published: 10-Nov-2015
Publisher: SAGE Publications
Citation: Journal of Cerebral Blood Flow and Metabolism, 2016, 36 (3), pp. 487-491
Abstract: Two multi-centre phase III clinical trials examining the protective potential of progesterone following traumatic brain injury have recently failed to demonstrate any improvement in outcome. Thus, it is timely to consider how this impacts on the translational potential of progesterone treatment for ischaemic stroke. A wealth of experimental evidence supports the neuroprotective properties of progesterone, and associated metabolites, following various types of central nervous system injury. In particular, for ischaemic stroke, studies have also begun to reveal possible mechanisms of such neuroprotection. However, the results in traumatic brain injury now question whether further clinical development of progesterone for ischaemic stroke is relevant.
DOI Link: 10.1177/0271678X15616782
ISSN: 0271-678X
eISSN: 1559-7016
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2015. This is an open-access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Reports, Dept. of Neuroscience, Psychology and Behaviour

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