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Title: Effects of statins on delirium following cardiac surgery - evidence from literature.
Authors: Mariscalco, Giovanni
Mariani, Silvia
Biancari, Fausto
Banach, Maciej
First Published: 2015
Publisher: Polskie Towarzystwo Psychiatryczne
Citation: Psychiatria Polska, 2015, 49 (6), pp. 1359-1370
Abstract: Delirium is a common complication after cardiac surgery, being associated with significant mortality and morbidity. The pathogenesis of postoperative delirium (POD) is complex and multifactorial, involving an interaction of multiple predisposing and precipitating factors. There are several hypothesis regarding the underlying mechanisms of POD, and the most recent emerging one involves neuroinflammation, which is exacerbated by the cardiopulmonary bypass-induced systemic inflammatory response. Experimental and clinical studies have recently documented improved perioperative central neural protection exerted by statins because of their anti-inflammatory, immunomodulatory, and antithrombotic properties. The present review will focused on the possible protective effect exerted by preoperative statin administration on delirium following cardiac surgery.
DOI Link: 10.12740/PP/60139
ISSN: 0033-2674
eISSN: 2391-5854
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2015, Polskie Towarzystwo Psychiatryczne. Deposited with reference to the publisher’s open access archiving policy.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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