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Title: Liquid pharmaceuticals formulation by eutectic formation
Authors: Abbott, Andrew P.
Ahmed, Essa I.
Prasad, Kamalesh
Qader, Idrees B.
Ryder, Karl S.
First Published: 8-May-2017
Publisher: Elsevier
Citation: Fluid Phase Equilibria, 2017, 448, pp. 2-8
Abstract: The amphiphilic nature of many pharmaceutical active ingredients often makes them difficult to solubilise and leads to significant wastage through non-optimal dosage. In this study it is shown that highly concentrated liquid formulations can be produced from pharmaceutical active ingredients which either contain a strong hydrogen bonding functionality e.g. -OH or -COOH or a quaternary ammonium moiety. These mixtures can overcome solubility issues in water as the eutectics prevent recrystallization of the active ingredient when dispersed in water. The depression of freezing point for these eutectic mixtures is modelled using the enthalpy of hydrogen bond formation which was calculated using calorimetric data. The study also demonstrates that complex drug molecules which exhibit polymorphism such as Adiphenine and Ranitidine can be formulated into a homogeneous liquid and the hydrogen bond donor can also be a pharmaceutical active ingredient e.g. aspirin.
DOI Link: 10.1016/j.fluid.2017.05.009
ISSN: 0378-3812
eISSN: 1879-0224
Embargo on file until: 8-May-2019
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © Elsevier 2017. After an embargo period this version of the paper will be an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License (, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Description: The file associated with this record is under embargo until 24 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, Dept. of Chemistry

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