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Title: Glomerular hyperfiltration - a new marker of metabolic risk
Authors: Tomaszewski, Maciej
Charchar, Fadi J.
Maric, Christine
McClure, John
Crawford, Lynne
Grzeszczak, Wladyslaw
Sattar, Naveed
Zukowska-Szczechowska, Ewa
Dominiczak, Anna F.
First Published: Apr-2007
Publisher: Nature Publishing Group
Citation: Kidney International, 2007, 71 (8), pp.816-821.
Abstract: Chronic kidney disease coexists with metabolic syndrome and this relationship may be apparent prior to overt manifestations of cardiovascular disease. To investigate early stages of the natural history of associations between renal function and metabolic syndrome, we phenotyped 1572 young (mean age - 18.4 yrs.), apparently healthy men for metabolic risk factors and estimated their creatinine clearance based on the Cockcroft-Gault equation. High metabolic risk (clustering of at least three metabolic risk factors) was revealed in 8.7% (137) of the subjects and was associated with a 6.9-fold increase in the odds of glomerular hyperfiltration (95% CI: 3.9-11.5) when compared to reference (from none to two metabolic risk factors). Overweight, elevated blood pressure and low HDL-cholesterol increased the multivariate-adjusted odds ratio of glomerular hyperfiltration to 6.6 (95% CI: 3.8-11.6), 1.8 (95% CI: 1.0-3.0) and 2.5 (95% CI: 1.5-4.3), respectively. Systolic and diastolic blood pressures clustered together with leptin in the factor analysis and this blood pressure-adiposity component correlated with estimated creatinine clearance (r=0.329, p<0.0001) and explained on its own 10.2% of the variance in the estimated renal function. Our data reveal the silent epidemics of metabolic risk among young, apparently healthy men. Furthermore, the results indicate that high metabolic risk is associated with glomerular hyperfiltration prior to overt manifestations of cardiovascular disease.
DOI Link: 10.1038/
Type: Article
Rights: This is the author's final draft of an article published in Kidney International by Nature Publishing Group. The final published paper is available via doi: 10.1038/
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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