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Title: Properdin plays a protective role in polymicrobial septic peritonitis
Authors: Stover, Cordula M.
Luckett, Jeni C.
Echtenacher, Bernd
Dupont, Aline
Figgitt, Sue E.
Brown, Jane
Mannel, Daniela M.
Schwaeble, Wilhelm J.
First Published: Mar-2008
Publisher: American Association of Immunologists
Citation: Journal of Immunology, 2008, 180, pp. 3313-3318.
Abstract: Properdin is a positive regulator of complement activation so far known to be instrumental in the survival of infections with certain serotypes of Neisseria meningitidis. We have generated a fully backcrossed properdin-deficient mouse line by conventional gene-specific targeting. In vitro, properdin-deficient serum is impaired in alternative pathway-dependent generation of complement fragment C3b when activated by Escherichia coli DH5α. Properdin-deficient mice and wild-type littermates compare in their levels of C3 and IgM. In an in vivo model of polymicrobial septic peritonitis induced by sublethal cecal ligation and puncture, properdin-deficient mice appear immunocompromised, because they are significantly impaired in their survival compared with wild-type littermates. We further show that properdin localizes to mast cells and that properdin has the ability to directly associate with E. coli DH5α. We conclude that properdin plays a significant role in the outcome of polymicrobial sepsis.
ISSN: 0022-1767
Type: Article
Description: This article was published as Journal of Immunology, 2008, 180, pp. 3313-3318. Copyright © American Association of Immunologists. It is available from
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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