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Title: B lymphocytes play a limited role in clearance of Campylobacter jejuni from the chicken intestinal tract
Authors: Lacharme-Lora, Lizeth
Chaloner, Gemma
Gilroy, Rachel
Humphrey, Suzanne
Gibbs, Kirsty
Jopson, Sue
Wright, Elli
Reid, William
Ketley, Julian
Humphrey, Tom
Williams, Nicola
Rushton, Steven
Wigley, Paul
First Published: 23-Mar-2017
Publisher: Nature Publishing Group
Citation: Scientific Reports, 2017, 7:45090
Abstract: Campylobacter jejuni is the leading cause of foodborne bacterial gastroenteritis with contaminated poultry meat its main source. Control of C. jejuni is a priority for the poultry industry but no vaccines are available and their development hampered by poor understanding of the immunobiology of C. jejuni infection. Here we show the functional role of B lymphocytes in response to C. jejuni in the chicken through depletion of the B lymphocyte population (bursectomy) followed by challenge. B lymphocyte depletion has little effect on bacterial numbers in the ceca, the main site of colonisation, where C. jejuni persist to beyond commercial slaughter age, but reduces clearance from the small intestine. In longer-term experiments we show antibody leads to reduction in C. jeuni numbers in the ceca by nine weeks post infection. Whilst we did not examine any protective role to re-challenge, it illustrates the difficulty in producing a vaccine in a young, immunologically naïve host. We believe this is first study of functional immunity to C. jejuni in chicken and shows antibody is ineffective in clearing C. jejuni from the ceca within the production lifetime of chickens, although is involved in clearance from the small intestine and longer-term clearance from the ceca.
DOI Link: 10.1038/srep45090
eISSN: 2045-2322
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2017. This is an open-access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Published Articles, Dept. of Genetics

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