Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/40356
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dc.contributor.authorLee, Kai K.-
dc.contributor.authorMatos, Sergio-
dc.contributor.authorWard, Katie-
dc.contributor.authorRafferty, Gerrard F.-
dc.contributor.authorMoxham, John-
dc.contributor.authorEvans, David H.-
dc.contributor.authorBirring, Surinder S.-
dc.date.accessioned2017-09-12T09:39:53Z-
dc.date.available2017-09-12T09:39:53Z-
dc.date.issued2017-05-01-
dc.identifier.citationBMJ Open Respiratory Research, 2017, 4 (1), e000178en
dc.identifier.issn2052-4439-
dc.identifier.urihttp://bmjopenrespres.bmj.com/content/4/1/e000178en
dc.identifier.urihttp://hdl.handle.net/2381/40356-
dc.description.abstractINTRODUCTION: Cough intensity is an important determinant of cough severity reported by patients. Cough sound analysis has been widely validated for the measurement of cough frequency but few studies have validated its use in the assessment of cough strength. We investigated the relationship between cough sound and physiological measures of cough strength. METHODS: 32 patients with chronic cough and controls underwent contemporaneous measurements of voluntary cough sound, flow and oesophageal pressure. Sound power, peak energy, rise-time, duration, peak-frequency, bandwidth and centroid-frequency were assessed and compared with physiological measures. The relationship between sound and subjective cough strength Visual Analogue Score (VAS), the repeatability of cough sounds and the effect of microphone position were also assessed. RESULTS: Sound power and energy correlated strongly with cough flow (median Spearman's r=0.87-0.88) and oesophageal pressure (median Spearman's r=0.89). Sound power and energy correlated strongly with cough strength VAS (median Spearman's r=0.84-0.86) and were highly repeatable (intraclass correlation coefficient=0.93-0.94) but both were affected by change in microphone position. CONCLUSIONS: Cough sound power and energy correlate strongly with physiological measures and subjective perception of cough strength. Power and energy are highly repeatable measures but the microphone position should be standardised. Our findings support the use of cough sound as an index of cough strength.en
dc.language.isoenen
dc.publisherBMJ Publishing Groupen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/28725446-
dc.rightsCopyright © the authors, 2017. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium non-commercially, provided the original author and source are credited.en
dc.subjectCough/Mechanisms/Pharmacologyen
dc.subjectLung Physiologyen
dc.subjectRespiratory Measurementen
dc.titleSound: a non-invasive measure of cough intensityen
dc.typeJournal Articleen
dc.identifier.doi10.1136/bmjresp-2017-000178-
dc.identifier.piibmjresp-2017-000178-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeJournal Article-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciencesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Cardiovascularen
dc.dateaccepted2017-03-29-
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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