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Title: Temporal stability of multiple trigger and episodic viral wheeze in early childhood
Authors: Spycher, Ben D.
Cochrane, Cara
Granell, Raquel
Sterne, Jonathan A. C.
Silverman, Michael
Pederson, Eva
Gaillard, Erol A.
Henderson, John
Kuehni, Claudia E.
First Published: 2-Nov-2017
Publisher: European Respiratory Society
Citation: European Respiratory Journal, 2017, 50: 1700014
Abstract: The distinction between episodic viral wheeze (EVW) and multiple trigger wheeze (MTW) is used to guide management of preschool wheeze. It has been questioned whether these phenotypes are stable over time. We examined the temporal stability of MTW and EVW in two large population-based cohorts. We classified children from the Avon Longitudinal Study on Parents and Children (N=10,970) and the Leicester Respiratory Cohorts (LRC, N=3,263) into EVW, MTW and no wheeze at ages 2, 4 and 6 years based on parent-reported symptoms. Using multinomial regression, we estimated relative risk ratios (RRRs) for EVW and MTW at follow-up (no wheeze as reference category) with and without adjusting for wheeze severity. Although large proportions of children with EVW and MTW became asymptomatic, those that continued to wheeze showed a tendency to remain in the same phenotype: Among children with MTW at 4 years in LRC the adjusted RRR was 15.6 (95% CI: 8.3, 29.2) for MTW (stable phenotype) compared to 7.0 (2.6, 18.9) for EVW (phenotype switching) at 6 years. The tendency to track was weaker for EVW and from 2-4 years. Results were similar across cohorts. This suggests that MTW and, to a lesser extent, EVW track regardless of wheeze severity.
DOI Link: 10.1183/13993003.00014-2017
ISSN: 0903-1936
eISSN: 1399-3003
Embargo on file until: 2-May-2019
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2017, European Respiratory Society. Deposited with reference to the publisher’s open access archiving policy.
Description: The file associated with this record is under embargo until 18 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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