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Title: Cryptochrome Is a Regulator of Synaptic Plasticity in the Visual System of Drosophila melanogaster
Authors: Damulewicz, Milena
Mazzotta, Gabriella M.
Sartori, Elena
Rosato, Ezio
Costa, Rodolfo
Pyza, Elzbieta M.
First Published: 30-May-2017
Publisher: Frontiers Media
Citation: Frontiers in Molecular Neuroscience, 2017, 10:165
Abstract: Drosophila CRYPTOCHROME (CRY) is a blue light sensitive protein with a key role in circadian photoreception. A main feature of CRY is that light promotes an interaction with the circadian protein TIMELESS (TIM) resulting in their ubiquitination and degradation, a mechanism that contributes to the synchronization of the circadian clock to the environment. Moreover, CRY participates in non-circadian functions such as magnetoreception, modulation of neuronal firing, phototransduction and regulation of synaptic plasticity. In the present study we used co-immunoprecipitation, yeast 2 hybrid (Y2H) and in situ proximity ligation assay (PLA) to show that CRY can physically associate with the presynaptic protein BRUCHPILOT (BRP) and that CRY-BRP complexes are located mainly in the visual system. Additionally, we present evidence that light-activated CRY may decrease BRP levels in photoreceptor termini in the distal lamina, probably targeting BRP for degradation.
DOI Link: 10.3389/fnmol.2017.00165
ISSN: 1662-5099
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2017. This is an open-access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Description: The Supplementary Material for this article can be found online at:
Appears in Collections:Published Articles, Dept. of Genetics

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