Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/40485
Title: Safety and efficacy of obinutuzumab with CHOP or bendamustine in previously untreated follicular lymphoma
Authors: Grigg, Andrew
Dyer, Martin J.S.
Díaz, Marcos G.
Dreyling, Martin
Rule, Simon
Lei, Guiyuan
Knapp, Andrea
Wassner-Fritsch, Elisabeth
Marlton, Paula
First Published: 1-Apr-2017
Publisher: Ferrata Storti Foundation with European Hematology Association
Citation: Haematologica, 2017, 102 (4), pp. 765-772
Abstract: The GAUDI study assessed safety and preliminary efficacy of induction therapy with obinutuzumab plus chemotherapy, followed by maintenance therapy with obinutuzumab alone, in previously untreated patients with follicular lymphoma. Assignment to chemotherapy was decided on a per-center basis before the patients' enrollment. Patients (n=81) received four to six cycles of obinutuzumab plus bendamustine every 4 weeks or six to eight cycles of obinutuzumab plus CHOP every 3 weeks. Patients with an end-of-treatment response were eligible for obinutuzumab maintenance therapy every 3 months for 2 years or until disease progression. Induction treatment was completed by 90% of patients in the obinutuzumab plus bendamustine group and 95% in the obinutuzumab plus CHOP group, while maintenance was completed by 81% and 72% of patients, respectively. All patients experienced at least one adverse event during induction, most commonly infusion-related reactions (58%), the majority of which were grade 1/2. The most common hematologic adverse event was grade 3/4 neutropenia (36% during induction and 7% during maintenance). One treatment-related death occurred during the maintenance phase. At the end of induction, 94% of patients had achieved an overall response, with complete response based on computed tomography in 36%. The progression-free survival rate at 36 months was 90% in the obinutuzumab plus bendamustine group and 84% in the obinutuzumab plus CHOP group. These results demonstrate that induction therapy with obinutuzumab plus bendamustine or obinutuzumab plus CHOP, followed by obinutuzumab maintenance, is associated with tolerable safety and promising efficacy. This study is registered at ClinicalTrials.gov as NCT00825149.
DOI Link: 10.3324/haematol.2016.152272
ISSN: 0390-6078
eISSN: 1592-8721
Links: http://www.haematologica.org/content/102/4/765.full.pdf+html
http://hdl.handle.net/2381/40485
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © Ferrata Storti Foundation, 2017. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium non-commercially, provided the original author and source are credited.
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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