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Title: Human Y-chromosome variation in the genome-sequencing era
Authors: Jobling, Mark A.
Tyler-Smith, Chris
First Published: 30-May-2017
Publisher: Nature Reviews Genetics
Citation: Nature Reviews Genetics, 2017, 18, pp. 485–497
Abstract: The properties of the human Y chromosome - namely, male specificity, haploidy and escape from crossing over - make it an unusual component of the genome, and have led to its genetic variation becoming a key part of studies of human evolution, population history, genealogy, forensics and male medical genetics. Next-generation sequencing (NGS) technologies have driven recent progress in these areas. In particular, NGS has yielded direct estimates of mutation rates, and an unbiased and calibrated molecular phylogeny that has unprecedented detail. Moreover, the availability of direct-to-consumer NGS services is fuelling a rise of 'citizen scientists', whose interest in resequencing their own Y chromosomes is generating a wealth of new data.
DOI Link: 10.1038/nrg.2017.36
ISSN: 1471-0056
eISSN: 1471-0064
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2017, Macmillan Publishers Ltd., part of Springer Nature. Deposited with reference to the publisher’s open access archiving policy.
Description: The file associated with this record is under embargo until 6 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, Dept. of Genetics

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