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Title: Proenkephalin in Heart Failure
Authors: Siong Chan, Daniel Chu
Cao, Thong Huy
Ng, Leong Loke
First Published: 28-Sep-2017
Publisher: Elsevier
Citation: Heart Failure Clinics, 2018, 14(1), pp. 1-11
Abstract: The opioid system is activated in heart failure, which may be cardioprotective but may also be counter-regulatory. Recently, systemic proenkephalin activation has been investigated in various conditions predicting mortality and kidney injury. In acute heart failure, proenkephalin independently predicts mortality and heart failure rehospitalization in addition to traditional risk markers. It also predicts worsening renal function, increasingly recognized as an important risk predictor for poor outcome in heart failure. This article explores the role of enkephalins and delta-opioid receptors in the heart, then reviews studies measuring proenkephalin levels in the circulation and their associations with prognosis.
DOI Link: 10.1016/j.hfc.2017.08.001
ISSN: 1551-7136
Embargo on file until: 28-Sep-2018
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2017, Elsevier. Deposited with reference to the publisher’s open access archiving policy.
Description: The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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