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Title: Nitric oxide interacts with monoamine oxidase to modulate aggression and anxiety-like behaviour.
Authors: Gutiérrez, Héctor Carreño
O'Leary, Aet
Freudenberg, Florian
Fedele, Giorgio
Wilkinson, Rob
Markham, Eleanor
van Eeden, Freek
Reif, Andreas
Norton, William H. J.
First Published: 23-Sep-2017
Publisher: Elsevier for European College of Neuropsychopharmacology
Citation: European Neuropsychopharmacology, 2017
Abstract: Nitric oxide (NO) is a gaseous neurotransmitter that has important behavioural functions in the vertebrate brain. In this study we compare the impact of decreased nitric NO signalling upon behaviour and neurobiology using both zebrafish and mouse. nitric oxide synthase mutant (nos1(-/-)) zebrafish show significantly reduced aggression and an increase in anxiety-like behaviour without altered production of the stress hormone cortisol. Nos1(-/-) mice also exhibit decreased aggression and are hyperactive in an open field test. Upon reduction of NO signalling, monoamine neurotransmitter metabolism is reduced as a consequence of decreased Monoamine oxidase activity. Treatment of nos1(-/-) zebrafish with the 5-HT receptor 1A agonist 8-OH-DPAT rescues aggression and some aspects of anxiety-like behaviour. Taken together, the interplay between NO and 5-HT appears to be critical to control behaviour. Our cross-species approach challenges the previous notion that reduced neuronal NOS leads to increased aggression. Rather, Nos1 knock-out can also lead to decreased aggression in some situations, a finding that may have implications for future translational research.
DOI Link: 10.1016/j.euroneuro.2017.09.004
ISSN: 0924-977X
eISSN: 1873-7862
Embargo on file until: 23-Sep-2018
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2017, Elsevier. Deposited with reference to the publisher’s open access archiving policy.
Description: The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Supplementary data associated with this article can be found in the online version at doi:10.1016/j.euroneuro.2017.09.004.
Appears in Collections:Published Articles, Dept. of Neuroscience, Psychology and Behaviour

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