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|Title:||Sexual lineage specific DNA methylation regulates Arabidopsis meiosis|
Higgins, James D.
|Publisher:||Nature Publishing Group|
|Citation:||Nature Genetics, 2017, In Press|
|Abstract:||DNA methylation controls eukaryotic gene expression and is extensively reprogrammed to regulate animal development. However, whether developmental methylation reprogramming during the sporophytic life cycle of flowering plants regulates genes is presently unknown. Here we report a distinctive, gene-targeted RNA-directed DNA methylation (RdDM) activity in the Arabidopsis thaliana male sexual lineage that regulates gene expression in meiocytes. Loss of sexual lineage-specific RdDM causes mis-splicing of the MPS1/PRD2 gene, thereby disrupting meiosis. Our results establish a regulatory paradigm in which de novo methylation creates a cell-lineage-specific epigenetic signature that controls gene expression and contributes to cellular function in flowering plants.|
|Embargo on file until:||1-Jan-10000|
|Rights:||Copyright © 2017, Nature Publishing Group. Deposited with reference to the publisher’s open access archiving policy.|
|Description:||The file associated with this record is under embargo until 6 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.|
|Appears in Collections:||Published Articles, Dept. of Genetics|
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|Walker et al.pdf||Post-review (final submitted author manuscript)||1.36 MB||Adobe PDF||View/Open|
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