Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/40604
Title: Sexual lineage specific DNA methylation regulates Arabidopsis meiosis
Authors: Walker, James
Gao, Hongbo
Zhang, Jingyi
Aldridge, Billy
Vickers, Martin
Higgins, James D.
Feng, Xiaoqi
First Published: 2017
Publisher: Nature Publishing Group
Citation: Nature Genetics, 2017, In Press
Abstract: DNA methylation controls eukaryotic gene expression and is extensively reprogrammed to regulate animal development. However, whether developmental methylation reprogramming during the sporophytic life cycle of flowering plants regulates genes is presently unknown. Here we report a distinctive, gene-targeted RNA-directed DNA methylation (RdDM) activity in the Arabidopsis thaliana male sexual lineage that regulates gene expression in meiocytes. Loss of sexual lineage-specific RdDM causes mis-splicing of the MPS1/PRD2 gene, thereby disrupting meiosis. Our results establish a regulatory paradigm in which de novo methylation creates a cell-lineage-specific epigenetic signature that controls gene expression and contributes to cellular function in flowering plants.
DOI Link: TBA
ISSN: 1061-4036
eISSN: 1546-1718
Links: TBA
http://hdl.handle.net/2381/40604
Embargo on file until: 1-Jan-10000
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2017, Nature Publishing Group. Deposited with reference to the publisher’s open access archiving policy.
Description: The file associated with this record is under embargo until 6 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, Dept. of Genetics

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