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Title: Clinical and biochemical factors associated with preeclampsia in women with obesity.
Authors: Vieira, Matias C.
Poston, Lucilla
Fyfe, Elaine
Gillett, Alexandra
Kenny, Louise C.
Roberts, Claire T.
Baker, Philip N.
Myers, Jenny E.
Walker, James J.
McCowan, Lesley M.
North, Robyn A.
Pasupathy, Dharmintra
SCOPE Consortium
First Published: 23-Dec-2016
Publisher: Wiley for Obesity Society
Citation: Obesity, 2017, 25 (2), pp. 460-467
Abstract: OBJECTIVE: To compare early pregnancy clinical and biomarker risk factors for later development of preeclampsia between women with obesity (body mass index, BMI ≥30 kg/m(2) ) and those with a normal BMI (20-25 kg/m(2) ). METHODS: In 3,940 eligible nulliparous women from the Screening for Pregnancy Endpoints (SCOPE) study, a total of 53 biomarkers of glucose and lipid metabolism, placental function, and known markers of preeclampsia were measured at 14 to 16 weeks' gestation. Logistic regression was performed to identify clinical and biomarker risk factors for preeclampsia in women with and without obesity. RESULTS: Among 834 women with obesity and 3,106 with a normal BMI, 77 (9.2%) and 105 (3.4%) developed preeclampsia, respectively. In women with obesity, risk factors included a family history of thrombotic disease, low plasma placental growth factor, and higher uterine artery resistance index at 20 weeks. In women with a normal BMI, a family history of preeclampsia or gestational hypertension, mean arterial blood pressure, plasma endoglin and cystatin C, and uterine artery resistance index were associated with preeclampsia, while high fruit intake was protective. CONCLUSIONS: Women with obesity and a normal BMI have different early pregnancy clinical and biomarker risk factors for preeclampsia.
DOI Link: 10.1002/oby.21715
ISSN: 1930-7381
eISSN: 1930-739X
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2016, Wiley for Obesity Society. Deposited with reference to the publisher’s open access archiving policy.
Description: The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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