Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/40653
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dc.contributor.authorSamani, Nilesh-
dc.contributor.authorProudlock, Frank A.-
dc.contributor.authorSiram, Vasantha-
dc.contributor.authorSuraweera, Chathurie-
dc.contributor.authorHutchinson, Claire-
dc.contributor.authorNelson, Christopher P.-
dc.contributor.authorAl-Uzri, Mohammed-
dc.contributor.authorGottlob, Irene-
dc.date.accessioned2017-12-01T11:09:34Z-
dc.date.issued2017-
dc.identifier.citationSchizophrenia Bulletin, in pressen
dc.identifier.issn0586-7614-
dc.identifier.issn1745-1701-
dc.identifier.uriTBCen
dc.identifier.urihttp://hdl.handle.net/2381/40653-
dc.descriptionThe file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.en
dc.description.abstractObjective Schizophrenia is associated with several brain deficits, as well as visual processing deficits, but clinically-useful biomarkers are elusive. We hypothesised that retinal layer changes, non-invasively visualized using spectral-domain optical coherence tomography (SD-OCT), may represent a possible “window” to these abnormalities. Methods A Leica EnvisuTM SD-OCT device was used to obtain high-resolution central foveal B-scans in both eyes of 35 patients with schizophrenia and 50 demographically-matched controls. Manual retinal layer segmentation was performed to acquire individual and combined layer thickness measurements in three macular regions. Contrast sensitivity was measured at three spatial frequencies in a sub-group of each cohort. Differences were compared using adjusted linear models and significantly different layer measures in patients underwent Spearman Rank correlations with contrast sensitivity, quantified symptoms severity, disease duration and antipsychotic medication dose. Results Total retinal and photoreceptor complex thickness was reduced in all regions in patients (P<0.0001). Segmentation revealed consistent thinning of the outer nuclear layer (P<0.001) and inner segment layer (P<0.05), as well as a pattern of parafoveal ganglion cell changes. Low spatial frequency contrast sensitivity was reduced in patients (P=0.002) and correlated with temporal parafoveal ganglion cell complex thinning (R=0.48, P=0.01). Negative symptom severity was inversely correlated with foveal photoreceptor complex thickness (R=-0.54, P=0.001) and outer nuclear layer thickness (R=-0.47, P=0.005). Samani et al. 4 Conclusions Our novel findings demonstrate considerable retinal layer abnormalities in schizophrenia that are related to clinical features and visual function. With time, SD-OCT could provide easily-measurable biomarkers to facilitate clinical assessment and further our understanding of the disease.en
dc.language.isoenen
dc.publisherOxford University Press (OUP) for Maryland Psychiatric Research Centeren
dc.rightsCopyright © 2017, Oxford University Press (OUP) for Maryland Psychiatric Research Center. Deposited with reference to the publisher’s open access archiving policy.en
dc.titleRetinal layer abnormalities as biomarkers of schizophreniaen
dc.typeJournal Articleen
dc.identifier.doi10.1093/schbul/sbx130-
dc.description.statusPeer-revieweden
dc.description.versionPost-printen
dc.type.subtypeArticle-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF LIFE SCIENCESen
pubs.organisational-group/Organisation/COLLEGE OF LIFE SCIENCES/MBSP Non-Medical Departmentsen
pubs.organisational-group/Organisation/COLLEGE OF LIFE SCIENCES/MBSP Non-Medical Departments/Neuroscience, Psychology and Behaviouren
pubs.organisational-group/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Health Sciencesen
pubs.organisational-group/Organisation/COLLEGE OF LIFE SCIENCES/Themesen
pubs.organisational-group/Organisation/COLLEGE OF LIFE SCIENCES/Themes/Neuroscience & Behaviouren
dc.rights.embargodate10000-01-01-
dc.dateaccepted2017-08-17-
Appears in Collections:Published Articles, Dept. of Neuroscience, Psychology and Behaviour

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