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Title: p63 in epithelial development.
Authors: Candi, Eleonora
Cipollone, Rita
Rivetti de Val Cervo, Pia
Gonfloni, Stefania
Melino, Gerry
Knight, Richard A.
First Published: 17-Jun-2008
Publisher: Springer Verlag
Citation: Cellular and Molecular Life Sciences, 2008, 65 (20), pp. 3126-3133.
Abstract: The epidermis, the outer layer of the skin composed of keratinocytes, is a stratified epithelium that functions as a barrier to protect the organism from dehydration and external insults. The epidermis develops following the action of the transcription factor p63, amember of the p53 family of transcription factors. The Trp63 gene contains two promoters driving the production of distinct proteins, one with an N-terminal transactivation domain (TAp63) and one without (ΔNp63), although their relative contribution to epidermal development is not clearly established. Trp63 mutations are involved in the pathogenesis of several human diseases, phenotypically characterized by ectodermal dysplasia. In this review, we summarize the current advances that have been made in understanding the role of p63 in epidermal morphogenesis.
ISSN: 1420-682X
Type: Article
Description: This is the author's final draft of the paper published as Cellular and Molecular Life Sciences, 2008, 65 (20), pp. 3126-3133. The original publication is available at Doi: 10.1007/s00018-008-8119-x
Appears in Collections:Published Articles, MRC Toxicology Unit

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