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Title: miRNAs, “stemness” and skin.
Authors: Aberdam, Daniel
Candi, Eleonora
Knight, Richard A.
Melino, Gerry
First Published: Oct-2008
Publisher: Elsevier.
Citation: Trends in Biochemical Sciences, 2008, 33 (12), pp. 583-591.
Abstract: The epidermis and its appendages provide organisms with protection from the environment, keeping pathogens out and preventing the loss of essential body fluids. To perform both functions, the skin has elaborated a complex differentiation process known as cornification. The skin‟s renewal capacity, responsible for maintaining tissue homeostasis, regenerating hair, and repairing the epidermis after injury, resides in the basal proliferating compartment where epidermal stem cells are located. These cells possess the remarkable capacity to both self-perpetuate and give rise to the differentiating cells that form mature tissues. Recent findings indicate that miRNAs play an essential role in orchestrating the formation of epidermis and skin appendages, in particular at the interface between stemness and differentiation.
DOI Link: 10.1016/j.tibs.2008.09.002
ISSN: 0968-0004
Type: Article
Rights: This is the author’s final draft of the paper published as Trends in Biochemical Sciences, 2008, 33 (12), pp. 583-591. The final published version is available at, Doi: 10.1016/j.tibs.2008.09.002.
Appears in Collections:Published Articles, MRC Toxicology Unit

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