Please use this identifier to cite or link to this item:
|Title:||miRNAs, “stemness” and skin.|
Knight, Richard A.
|Citation:||Trends in Biochemical Sciences, 2008, 33 (12), pp. 583-591.|
|Abstract:||The epidermis and its appendages provide organisms with protection from the environment, keeping pathogens out and preventing the loss of essential body fluids. To perform both functions, the skin has elaborated a complex differentiation process known as cornification. The skin‟s renewal capacity, responsible for maintaining tissue homeostasis, regenerating hair, and repairing the epidermis after injury, resides in the basal proliferating compartment where epidermal stem cells are located. These cells possess the remarkable capacity to both self-perpetuate and give rise to the differentiating cells that form mature tissues. Recent findings indicate that miRNAs play an essential role in orchestrating the formation of epidermis and skin appendages, in particular at the interface between stemness and differentiation.|
|Rights:||This is the author’s final draft of the paper published as Trends in Biochemical Sciences, 2008, 33 (12), pp. 583-591. The final published version is available at http://www.elsevier.com/wps/find/journaldescription.cws_home/405916/description#description, Doi: 10.1016/j.tibs.2008.09.002.|
|Appears in Collections:||Published Articles, MRC Toxicology Unit|
Files in This Item:
|TIBS 08-00067 final text.pdf||499.53 kB||Adobe PDF||View/Open|
Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.