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Title: The α1L-adrenoceptor is an alternative phenotype of the α1A-adrenoceptor.
Authors: Nelson, Carl P.
First Published: 23-Jun-2008
Publisher: Nature Publishing Group
Citation: British Journal od Pharmacology, 2008, 155 (1), pp. 1-3
Abstract: Despite over two decades of research, the molecular identity of the α1L-adrenoceptor phenotype has remained elusive. Gray et al. (2008) present results in this issue of the journal that provide persuasive evidence that the in vivo α1L-adrenoceptor phenotype requires the expression of the α1A-adrenoceptor gene. They have shown that in mice lacking the functional α1A-adrenoceptor gene, α1L-mediated responses to noradrenaline in prostate smooth muscle are substantially attenuated. These findings support earlier evidence that the α1L-adrenoceptor profile represents a functional phenotype of the α1A-adrenoceptor gene product, but additional cell background-dependent factors must act in concert with the α1A-adrenoceptor protein to determine whether an α1L- or a classical α1A-adrenoceptor profile is expressed. The challenge remains to establish the nature of these cellular factors and the mechanism(s) by which they influence G-protein coupled receptor pharmacology.
ISSN: 0007-1188
Type: Article
Description: This is the author's final draft of the paper published as British Journal of Pharmacology, 2008, 155 (1), pp. 1-3. The final published version is available at, Doi: 10.1038/bjp.2008.264
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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