Leicester Research Archive

Leicester Research Archive >
College of Medicine, Biological Sciences and Psychology >
Cell Physiology and Pharmacology, Department of >
Published Articles, Dept. of Cell Physiology and Pharmacology >

Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/4124

Title: The α1L-adrenoceptor is an alternative phenotype of the α1A-adrenoceptor.
Authors: Nelson, Carl P.
Issue Date: 23-Jun-2008
Publisher: Nature Publishing Group
Citation: British Journal od Pharmacology, 2008, 155 (1), pp. 1-3
Abstract: Despite over two decades of research, the molecular identity of the α1L-adrenoceptor phenotype has remained elusive. Gray et al. (2008) present results in this issue of the journal that provide persuasive evidence that the in vivo α1L-adrenoceptor phenotype requires the expression of the α1A-adrenoceptor gene. They have shown that in mice lacking the functional α1A-adrenoceptor gene, α1L-mediated responses to noradrenaline in prostate smooth muscle are substantially attenuated. These findings support earlier evidence that the α1L-adrenoceptor profile represents a functional phenotype of the α1A-adrenoceptor gene product, but additional cell background-dependent factors must act in concert with the α1A-adrenoceptor protein to determine whether an α1L- or a classical α1A-adrenoceptor profile is expressed. The challenge remains to establish the nature of these cellular factors and the mechanism(s) by which they influence G-protein coupled receptor pharmacology.
ISSN: 0007-1188
1476-5381
Links: http://www.nature.com/bjp/journal/v155&#(...)
http://dx.doi.org/10.1038/bjp.2008.264
http://hdl.handle.net/2381/4124
Type: Article
Description: This is the author's final draft of the paper published as British Journal of Pharmacology, 2008, 155 (1), pp. 1-3. The final published version is available at http://www.nature.com/bjp/journal/v155/n1/index.html, Doi: 10.1038/bjp.2008.264
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

Files in This Item:

File Description SizeFormat
alpha 1L commentary.pdf94.65 kBAdobe PDFView/Open
View Statistics

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.

 

MAINTAINER