Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/41282
Title: Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits
Authors: Howe, Laurence J.
Erzurumluoglu, Mesut A.
Davey Smith, George
Rodriguez, Santiago
Stergiakouli, Evie
First Published: 14-Sep-2017
Publisher: Nature Publishing Group
Citation: Scientific Reports, 2017, 7, Article number: 11655
Abstract: Many psychiatric traits are sexually dimorphic in terms of prevalence, age of onset, progression and prognosis; sex chromosomes could play a role in these differences. In this study we evaluated the association between Y chromosome and mitochondrial DNA haplogroups with sexually-dimorphic behavioural and psychiatric traits. The study sample included 4,211 males and 4,009 females with mitochondrial DNA haplogroups and 4,788 males with Y chromosome haplogroups who are part of the Avon Longitudinal Study of Parents and Children (ALSPAC) based in the United Kingdom. Different subsets of these populations were assessed using measures of behavioural and psychiatric traits with logistic regression being used to measure the association between haplogroups and the traits. The majority of behavioural traits in our cohort differed between males and females; however Y chromosome and mitochondrial DNA haplogroups were not associated with any of the variables. These findings suggest that if there is common variation on the Y chromosome and mitochondrial DNA associated with behavioural and psychiatric trait variation, it has a small effect.
DOI Link: 10.1038/s41598-017-10871-4
eISSN: 2045-2322
Links: http://www.nature.com/articles/s41598-017-10871-4
http://hdl.handle.net/2381/41282
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2017. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Published Articles, Dept. of Health Sciences

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