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Title: t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
Authors: Russell, Lisa J.
Akasaka, Takashi
Majid, Aneela
Sugimoto, Kei-ji
Karran, E. Loraine
Nagel, Inga
Harder, Lana
Claviez, Alexander
Gesk, Stefan
Moorman, Anthony V.
Ross, Fiona
Mazzullo, Helen
Strefford, Jonathan C.
Siebert, Reiner
Dyer, Martin J. S.
Harrison, Christine J.
First Published: 1-Jan-2008
Publisher: American Society of Hematology
Citation: Blood, 2008, 111 (1), pp. 387-391.
Abstract: Translocations involving the immunoglobulin heavy chain locus (IGH@) at chromosome band 14q32 are common in mature B-cell neoplasms, but are rare in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Here, we report the translocation, t(6;14)(p22;q32), involving IGH@ as a novel recurrent translocation in 13 BCP-ALL patients. Fluorescence in situ hybridization and long-distance inverse polymerase chain reaction identified ID4 as the partner gene. Breakpoints were scattered over a 19kb region centromeric of ID4. Quantitative real-time PCR showed upregulation of ID4 mRNA. All patients had deletions of CDKN2A and PAX5 located on the short arm of chromosome 9, frequently as a result of an isochromosome, i(9)(q10) (9/13, 69%). This study defines a new subgroup of BCP-ALL characterized by ID4 over-expression and CDKN2A and PAX5 deletions. Preliminary survival data suggest that this subgroup may be associated with a good response to therapy.
DOI Link: 10.1182/blood-2007-07-092015
ISSN: 0006-4971
Type: Article
Rights: This is the author's final draft of the paper published as Blood, 2008, 111 (1), pp. 387-391. Copyright © 2008 American Society of Hematology. This material is posted here with permission of the American Society of Hematology. The final version can be obtained from Doi: 10.1182/blood-2007-07-092015
Appears in Collections:Published Articles, MRC Toxicology Unit

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