Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/4162
Title: Evaluation of the prognostic value of systemic inflammation and socioeconomic deprivation in patients with resectable colorectal liver metastases.
Authors: Neal, Christopher P.
Mann, Christopher D.
Sutton, C. D.
Garcea, G.
Ong, S. L.
Steward, William P.
Dennison, A.R.
Berry, David P.
First Published: Jan-2009
Publisher: Elsevier
Citation: European Journal of Cancer, 2009, 45 (1), pp. 56-64.
Abstract: Background: There is increasing evidence that the presence of a pre-operative systemic inflammatory response (SIR) independently predicts poor long-term outcome in patients with colorectal cancer (CRC). Socioeconomic deprivation was reported to correlate with the presence of the SIR and to independently predict poor outcome following primary CRC resection. The aim of this study was to determine the prognostic value of pre-operative systemic inflammatory biomarkers and socioeconomic deprivation in patients undergoing resection of colorectal liver metastases (CLM) and to examine correlations between these variables in this context. Patients and methods: Clinicopathological data, including the Memorial Sloan-Kettering Cancer Centre Clinical Risk Score (CRS), were obtained from a prospectively maintained database for 174 patients who underwent hepatectomy for CLM between January 2000 and December 2005 at a single United Kingdom (UK) tertiary referral hepatobiliary centre. Inflammatory biomarkers (total and differential leucocyte counts, neutrophil–lymphocyte ratio, platelet count, haemoglobin, and serum albumin) were measured from routine pre-operative blood tests. Socioeconomic deprivation was measured using the Carstairs deprivation score. Results: On multivariable analysis, poor CRS (3–5), high neutrophil count (>6.0 × 109/l) and low serum albumin (<40 g/dl) were the only independent predictors of shortened overall survival following metastasectomy, with neutrophil count representing the greatest relative risk of death. These factors were also the only independent predictors of shortened disease-free survival following hepatectomy. Socioeconomic deprivation was associated with neither systemic inflammation nor long-term outcome in this context. Conclusions: The presence of a pre-operative systemic inflammatory response, but not socioeconomic deprivation, independently predicts shortened survival following resection of CLM.
DOI Link: 10.1016/j.ejca.2008.08.019
ISSN: 0959-8049
Links: http://www.sciencedirect.com/science/article/pii/S0959804908006801
http://hdl.handle.net/2381/4162
Type: Article
Rights: This is the author's final draft of the paper published as European Journal of Cancer, 2009, 45 (1), pp. 56-64. The final version is available from http://www.sciencedirect.com. Doi: 10.1016/j.ejca.2008.08.019
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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