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Title: A Model for Simultaneous Crystallisation and Biodegradation of Biodegradable Polymers.
Authors: Han, Xiaoxiao
Pan, Jingzhe
First Published: 25-Oct-2008
Publisher: Elsevier.
Citation: Biomaterials, 2008, 30 (3), pp. 423-430.
Abstract: This paper completes the model of biodegradation for biodegradable polymers that was previously developed by Wang et al. (Wang Y, Pan J, Han X, Sinka, Ding L. A phenomenological model for the degradation of biodegradable polymers. Biomaterials 2008;29:3393-3401). Crystallisation during biodegradation was not considered in the previous work which is the topic of the current paper. For many commonly used biodegradable polymers, there is a strong interplay between crystallisation and hydrolysis reaction during biodegradation – the chain cleavage caused by the hydrolysis reaction provides an extra mobility for the polymer chains to crystallise and the resulting crystalline phase becomes more resistant to further hydrolysis reaction. This paper presents a complete theory to describe this interplay. The fundamental equations in the Avrami’s theory for crystallisation are modified and coupled to the diffusion-reaction equations that were developed in our previous work. The mathematical equations are then applied to three biodegradable polymers for which long term degradation data are available in the literature. It is shown that the model can capture the behaviour of the major biodegradable polymers very well.
DOI Link: 10.1016/j.biomaterials.2008.10.001
ISSN: 0142-9612
Type: Article
Rights: This is the author’s final draft of the paper published as Biomaterials, 2008, 30 (3), pp. 423-430. The final published version is available at, Doi: 10.1016/j.biomaterials.2008.10.001.
Appears in Collections:Published Articles, Dept. of Engineering

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