Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMacKinnon, Heather J.-
dc.contributor.authorWilkinson, Thomas J.-
dc.contributor.authorClarke, Amy L.-
dc.contributor.authorGould, Douglas W.-
dc.contributor.authorO’Sullivan, Thomas F.-
dc.contributor.authorXenophontos, Soteris-
dc.contributor.authorWatson, Emma L.-
dc.contributor.authorSingh, Sally J.-
dc.contributor.authorSmith, Alice C.-
dc.identifier.citationTherapeutic Advances in Chronic Disease, 2018, In Pressen
dc.descriptionThe file associated with this record is under embargo until publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.en
dc.description.abstractObjective: People with non-dialysis dependent chronic kidney disease (CKD) and renal transplant recipients (RTR) have compromised physical function and reduced physical activity (PA) levels. Whilst established in healthy older adults and other chronic diseases, this association remains underexplored in CKD. We aimed to review the existing research investigating poor physical function and PA with clinical outcome in non-dialysis CKD. Data sources: Electronic databases (PubMed, MEDLINE, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials) were searched until December 2017 for cohort studies reporting objective/subjective measures of PA/physical function and the associations with adverse clinical outcomes/all-cause mortality for patients with non-dialysis chronic kidney disease stages 1 to 5 and RTR. The protocol was registered on the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42016039060). Review methods: Study quality was assessed using the Newcastle-Ottawa Scale and the Agency for Healthcare and Research Quality (AHRQ) standards. Results: 29 studies were included; 12 reporting on physical function and 17 on PA. Only 8 studies were conducted with RTR. The majority were classified as “Good” according to the AHRQ standards. Although not appropriate for meta-analysis due to variance in the outcome measures reported, a coherent pattern was seen with higher mortality rates and/or prevalence of adverse clinical events associated with lower PA and physical function levels, irrespective of the measurement tool used. Sources of bias included incomplete description of participant flow through the study and over-reliance on self-report measures. Conclusions: In non-dialysis CKD, survival rates correlate with greater PA and physical function levels. Further trials are required to investigate causality and the effectiveness of physical function/physical activity interventions in improving outcomes. Future work should identify standard assessment protocols for PA and physical function.en
dc.description.sponsorshipThis report is independent research supported by the National Institute for Health Research Leicester Biomedical Research Centre and the NIHR Collaboration for Leadership in Applied Health Research and Care East Midlands (CLAHRC EM). We also gratefully acknowledge additional funding from The Stoneygate Trust.en
dc.publisherSAGE Publications (UK and US)en
dc.rightsCopyright © 2018, SAGE Publications (UK and US). Deposited with reference to the publisher’s open access archiving policy. (
dc.subjectkidney diseasesen
dc.subjectkidney transplantationen
dc.subjectphysical activityen
dc.subjectphysical functionen
dc.titleThe association of physical function and physical activity with all-cause mortality and adverse clinical outcomes in non-dialysis chronic kidney disease: a systematic review.en
dc.typeJournal Articleen
pubs.organisational-group/Organisation/COLLEGE OF LIFE SCIENCESen
pubs.organisational-group/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Infection, Immunity and Inflammationen
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

Files in This Item:
File Description SizeFormat 
MacKinnon, Wilkinson, Clarke et al 2018 Systematic review PF PA in predialysis CKD Ther Adv Chr Dis_Final Accepted Version.pdfPost-review (final submitted author manuscript)538.11 kBAdobe PDFView/Open

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.