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Title: Metabolomic profiling of maternal hair suggests rapid development of intrahepatic cholestasis of pregnancy
Authors: de Seymour, Jamie V.
Tu, Stephanie
He, Xiaoling
Zhang, Hua
Han, Ting-Li
Baker, Philip N.
Sulek, Karolina
First Published: 26-May-2018
Publisher: Springer Verlag (Germany) for Metabolomics Society
Citation: Metabolomics, 2018, 14: 79
Abstract: Introduction Intrahepatic cholestasis of pregnancy (ICP) is a common maternal liver disease; development can result in devastating consequences, including sudden fetal death and stillbirth. Currently, recognition of ICP only occurs following onset of clinical symptoms. Objective Investigate the maternal hair metabolome for predictive biomarkers of ICP. Methods The maternal hair metabolome (gestational age of sampling between 17 and 41 weeks) of 38 Chinese women with ICP and 46 pregnant controls was analysed using gas chromatography–mass spectrometry. Results Of 105 metabolites detected in hair, none were significantly associated with ICP. Conclusion Hair samples represent accumulative environmental exposure over time. Samples collected at the onset of ICP did not reveal any metabolic shifts, suggesting rapid development of the disease.
DOI Link: 10.1007/s11306-018-1371-7
ISSN: 1573-3882
eISSN: 1573-3890
Embargo on file until: 26-May-2019
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2018, Springer Verlag (Germany) for Metabolomics Society. Deposited with reference to the publisher’s open access archiving policy. (
Description: The online version of this article ( contains supplementary material, which is available to authorized users.
The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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