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Title: Identification and Characterization of the Dermal Panniculus Carnosus Muscle Stem Cells.
Authors: Naldaiz-Gastesi, Neia
Goicoechea, María
Alonso-Martín, Sonia
Aiastui, Ana
López-Mayorga, Macarena
García-Belda, Paula
Lacalle, Jaione
San José, Carlos
Araúzo-Bravo, Marcos J.
Trouilh, Lidwine
Anton-Leberre, Véronique
Herrero, Diego
Matheu, Ander
Bernad, Antonio
García-Verdugo, José Manuel
Carvajal, Jaime J.
Relaix, Frédéric
Lopez de Munain, Adolfo
García-Parra, Patricia
Izeta, Ander
First Published: 1-Sep-2016
Publisher: Elsevier (Cell Press)
Citation: Stem Cell Reports, 2016, 7 (3), pp. 411-424
Abstract: The dermal Panniculus carnosus (PC) muscle is important for wound contraction in lower mammals and represents an interesting model of muscle regeneration due to its high cell turnover. The resident satellite cells (the bona fide muscle stem cells) remain poorly characterized. Here we analyzed PC satellite cells with regard to developmental origin and purported function. Lineage tracing shows that they originate in Myf5(+), Pax3/Pax7(+) cell populations. Skin and muscle wounding increased PC myofiber turnover, with the satellite cell progeny being involved in muscle regeneration but with no detectable contribution to the wound-bed myofibroblasts. Since hematopoietic stem cells fuse to PC myofibers in the absence of injury, we also studied the contribution of bone marrow-derived cells to the PC satellite cell compartment, demonstrating that cells of donor origin are capable of repopulating the PC muscle stem cell niche after irradiation and bone marrow transplantation but may not fully acquire the relevant myogenic commitment.
DOI Link: 10.1016/j.stemcr.2016.08.002
eISSN: 2213-6711
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2016. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License (, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Description: Transcriptomic data of dermal cell fractions are deposited in NCBI’s Gene Expression Omnibus (Edgar et al., 2002) under accession number GEO: GSE67693.
Appears in Collections:Published Articles, School of Archaeology and Ancient History

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