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|Title:||Identification and Characterization of the Dermal Panniculus Carnosus Muscle Stem Cells.|
San José, Carlos
Araúzo-Bravo, Marcos J.
García-Verdugo, José Manuel
Carvajal, Jaime J.
Lopez de Munain, Adolfo
|Publisher:||Elsevier (Cell Press)|
|Citation:||Stem Cell Reports, 2016, 7 (3), pp. 411-424|
|Abstract:||The dermal Panniculus carnosus (PC) muscle is important for wound contraction in lower mammals and represents an interesting model of muscle regeneration due to its high cell turnover. The resident satellite cells (the bona fide muscle stem cells) remain poorly characterized. Here we analyzed PC satellite cells with regard to developmental origin and purported function. Lineage tracing shows that they originate in Myf5(+), Pax3/Pax7(+) cell populations. Skin and muscle wounding increased PC myofiber turnover, with the satellite cell progeny being involved in muscle regeneration but with no detectable contribution to the wound-bed myofibroblasts. Since hematopoietic stem cells fuse to PC myofibers in the absence of injury, we also studied the contribution of bone marrow-derived cells to the PC satellite cell compartment, demonstrating that cells of donor origin are capable of repopulating the PC muscle stem cell niche after irradiation and bone marrow transplantation but may not fully acquire the relevant myogenic commitment.|
|Rights:||Copyright © the authors, 2016. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.|
|Description:||Transcriptomic data of dermal cell fractions are deposited in NCBI’s Gene Expression Omnibus (Edgar et al., 2002) under accession number GEO: GSE67693.|
|Appears in Collections:||Published Articles, School of Archaeology and Ancient History|
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