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Title: Chronic kidney disease, worsening renal function and outcomes in a heart failure community setting: A UK national study
Authors: Lawson, Claire A.
Testani, J. M.
Mamas, M.
Damman, K.
Jones, P. W.
Teece, L.
Kadam, U. T.
First Published: 27-Jun-2018
Publisher: Elsevier, International Society for Adult Congenital Heart Disease
Citation: International Journal of Cardiology, 2018, 267, pp. 120-127 (8)
Abstract: Background Routine heart failure (HF) monitoring and management is in the community but the natural course of worsening renal function (WRF) and its influence on HF prognosis is unknown. We investigated the influence of routinely monitored renal decline and related comorbidities on imminent hospitalisation and death in the HF community population. Methods A nested case-control study within an incident HF cohort (N = 50,114) with 12-years follow-up. WRF over 6-months before first hospitalisation and 12-months before death was defined by >20% reduction in estimated glomerular filtration rate (eGFR). Additive interactions between chronic kidney disease (CKD) and comorbidities were investigated. Results Prevalence of CKD (eGFR<60 ml/min/1.73m2) in the HF community was 63%, which was associated with an 11% increase in hospitalisation and 17% in mortality. Both risk associations were significantly worse in the presence of diabetes. Compared to HF patients with eGFR,60–89, there was no or minimal increase in risk for mild to moderate CKD (eGFR,30–59) for both outcomes. Adjusted risk estimates for hospitalisation were increased only for severe CKD(eGFR,15–29); Odds Ratio 1.49 (95%CI;1.36,1.62) and renal failure(eGFR,<15); 3.38(2.67,4.29). The relationship between eGFR and mortality was U-shaped; eGFR, ≥90; 1.32(1.17,1.48), eGFR,15–29; 1.68(1.58,1.79) and eGFR,<15; 3.04(2.71,3.41). WRF is common and associated with imminent hospitalisation (1.50;1.37,1.64) and mortality (1.92;1.79,2.06). Conclusions In HF, the risk associated with CKD differs between the community and the acute HF setting. In the community setting, moderate CKD confers no risk but severe CKD, WRF or CKD with other comorbidities identifies patients at high risk of imminent hospitalisation and death.
DOI Link: 10.1016/j.ijcard.2018.04.090
ISSN: 0167-5273
eISSN: 1874-1754
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2018. This is an open-access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Description: Supplementary data to this article can be found online at
Appears in Collections:Published Articles, Dept. of Health Sciences

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